國立陽明大學醫學士
台北榮民總醫院神經內科住院醫師
國立陽明大學臨床醫學研究所博士
桃園榮民醫院急診及神經內科主治醫師
哈佛醫學院麻州總醫院神經血管研究室博士後研究員
台灣頭痛學會秘書長
亞洲區域頭痛聯盟秘書長 (Secretary General, Asian Regional Consortium of Headache)
日本慶應大學國際客座教授
國際頭痛學會官方期刊Cephalalgia副主編(Associate Editor, Cephalalgia)
國際頭痛學會官方期刊子期刊Cephalalgia Reports副主編(Associate Editor, Cephalalgia Reports)
台北榮民總醫院醫學科技大樓管理中心主任
台北榮民總醫院教師培育研究技巧課程規畫小組主席

臨床專長: 頭痛、失智症、帕金森氏症及神經免疫疾病。

研究主題:

1. 頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。
偏頭痛是造成最多疾病負擔的神經科疾病，造成的失能人年數在世界所有慢性疾病裡排名第二，對社會經濟與醫療體系造成巨大的衝擊，但其病生理機轉尚未釐清，治療選擇亦有限。團隊以創新神經影像技術結合電生理、基因、動物模式探討頭痛與複雜性神經血管疾病的病生理機轉並促進疾病的診斷治療與預防。部分研究成果包括建立偏頭痛複合式多體學診斷模型 (Brain 2025)、釐清偏頭痛神經發炎的分子生物機轉 (Brain 2017& 2023) 亦發表了台灣及亞洲第一個偏頭痛、叢發性頭痛、眩暈症之全基因體關聯性研究，找到台灣人頭痛或其共病特有的基因，提供未來病生理機轉研究重要方向。目前正持續透過臨床或基礎的研究，開發新的頭痛動物模式及深入探討偏頭痛基因體與腦連結體間的交互影響，希望未來可提供疾病新診斷或治療之契機，進而減輕病患及醫療體系負擔。

2. 雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究
RCVS是最嚴重最危險的複雜性神經血管疾病之一，其主要臨床表現為反覆發作如爆炸般的頭痛(雷擊頭痛)合併血管收縮，這些劇烈頭痛讓病患嚴重失能、反覆至急診就診、甚至因此害怕從事這些日常生活活動，影響生活甚鉅，且病患有相當風險產生缺血性中風、腦出血或腦後方白質病變等併發症。針對RCVS，我們從釐清其臨床表現與病程、建立檢查與治療標準流程準則、找出其預測併發症的準則及長期預後、 開發新影像技術協助診治乃至病生理機轉的探討，已發表系列論文於國際知名期刊如JAMA Neurology, Annals of Neurology, Neurology, Cephalalgia等,研究成果質與量居國際領先地位。目前團隊正致力於開發新的影像診斷工具結合多體學研究深入探討其病生理機轉。

3. 膠淋巴系統與腦膜淋巴系統於神經疾病致病機轉扮演角色
膠淋巴系統（Glymphatic System）與腦膜淋巴系統（Meningeal Lymphatic System）是近年發現的重要系統，在多種神經疾病的致病機轉中扮演關鍵角色，主要涉及腦內廢物清除、免疫調節及神經發炎。本團隊建立人類及實驗動物之膠淋巴系統與腦膜淋巴系統之影像研究平台，以雙向轉譯研究模式全方面探討疾病病生理機轉。目前已有多篇文章發表於Annals of Neurology, The Journal of Headache and Pain, European Radiology。

2024 台北榮民總醫院醫師學術論文獎第一名
2024 行政院退輔會台北榮民總醫院優良醫師獎
2024 國立陽明交通大學醫學系優良教師獎
2024 行政院退輔會研究計畫報告特優獎
2023 國立陽明交通大學醫學系優良教師獎
2022 科技部110年度傑出研究獎
2022 台北榮民總醫院醫師學術論文獎
2022 國立陽明交通大學醫學系優良教師獎
2021 台北榮總醫師創新(改良)獎第一名
2021 第17屆永信李天德醫藥科技獎－青年醫藥科技獎
2021 國立陽明交通大學醫學院院級教學傑出獎
2021 國立陽明交通大學臨床醫學研究所優良教師獎
2021 國立陽明交通大學醫學系優良教師獎
2020 國立陽明大學醫學院院級教學傑出獎
2020 國立陽明大學研究所票選特色教學傑出獎
2020 國立陽明大學臨床醫學研究所優良教師獎
2020 國立陽明大學醫學系優良教師獎
2019 科技部吳大猷先生紀念獎
2019 國立陽明大學醫學系優良教師獎
2019 國立陽明大學臨床醫學研究所「優良教師獎」
2019 國立陽明大學院級教學傑出獎
2019 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」
2018 國立陽明大學醫學系優良教師獎
2018 行政院退輔會台北榮民總醫院優良醫師獎
2018 國際疼痛研究學會官方雜誌(Pain)最高引用次數學術論文獎
2018 國立陽明大學醫學系良師益友導師獎
2017 國立陽明大學醫學系優良教師獎 (琉璃獎座)
2016 國立陽明大學醫學系優良教師獎
2016 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」
2015 國立陽明大學醫學系優良教師獎
2013 榮陽卓越醫師人才培育計畫獎助
2011 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」
2009 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」
2009 台灣神經學會頭痛學組最佳壁報論文獎
2008 台灣神經學會頭痛學組最佳壁報論文獎
2006 台灣神經學會頭痛學組最佳壁報論文獎

近期研究著作 (2020-2025, *corresponding author)

1. Chen SP, Chang YH, Wang YF, Chen HY*, Wang SJ*. Composite microRNA-genetic risk score model links to migraine and implicates its pathogenesis. Brain 2025 Jan 18:awaf005. doi: 10.1093/brain/awaf005.
2. Kuan AS, Wang YF, Chen SP, Chuang YF, Wang SJ. Sex differences in pain, suicidal ideation, and suicide attempts in patients with migraine. Headache 2025 Jan 24. doi: 10.1111/head.14906.
3. Tokuyasu D, Imai S, Chen SP, Ihara K, Watanabe N, Izawa Y, Nakahara J, Hori S, Takizawa T. Vertebral artery dissection in a patient with migraine treated with calcitonin gene-related peptide monoclonal antibody: a case report and FAERS database analysis. BMC Neurol. 2025 Jan 2;25(1):1. doi: 10.1186/s12883-024-04009-z.
4. Yeh JT, Wang YF, Tzeng YS, Chen SP, Pan LLH, Wang SJ.* Exploring the Impact of Acute SARS-CoV-2 Infection on Headache Pattern in Migraine Patients: A Novel Bayesian Analysis. Headache 2025 Feb 10. doi: 10.1111/head.14911.
5. Liao YH, Tzeng YS, Chen SP, Ling YH, Chen WT, Wang SJ, Wang YF*. Association between headache frequency and risk for fibromyalgia in patients with migraine. Cephalalgia 2025 Feb;45(2):3331024251317486.
6. Wu CH, Chang FC, Wang YF, Lirng JF, Wu HM, Pan LLP, Wang SJ*, Chen SP* Impaired glymphatic and meningeal lymphatic functions in patients with chronic migraine. Annals of Neurology 2024 Jan;95:583–595
7. Wu CH, Lee PL, Wang YF, Lirng JF, Chen ST, Lin CJ, Wang SJ*, Chou KH*, Chen SP*. Phasic perfusion dynamics among migraine subtypes: A multimodel arterial spin labeling investigation. The Journal of Headache and Pain 2024; 25:167. https://doi.org/10.1186/s10194-024-01880-6
8. Hsiao FJ, Chen WT, Liu HY, Wu YT, Wang YF, Pan LLP, Lai KL, Chen SP, Coppola G, Wang SJ. Altered brainstem–cortex activation and interaction in migraine patients: somatosensory evoked EEG responses with machine learning. The Journal of Headache and Pain 2024; 25:185. https://doi.org/10.1186/s10194-024-01892-2
9. Wu JW, Chen ST, Wang YF, Chen SP, Tseng SY, Chen WT, Chiang CC, Wang SJ. Pre-cluster symptoms in a Taiwanese cohort of cluster headache: Symptom profiles and clinical predictions. The Journal of Headache and Pain 2024 Oct 8;25(1):174.
10. Liu TT, Chen SP, Wang SJ, Yen JC.* Vagus nerve stimulation inhibits cortical spreading depression via glutamate-dependent TrkB activation mechanism in the nucleus tractus solitarius. Cephalalgia 2024 Feb;44(2):3331024241230466. doi: 10.1177/03331024241230466.
11. Wu CH, Kuo Y, Ling YH, Wang YF, Fuh JL, Lirng JF, Wu HM, Wang SJ*, Chen SP* Dynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome. The Journal of Headache and Pain 2024 Feb 5;25(1):17. doi: 10.1186/s10194-024-01726-1.
12. Liaw YC, Chen SP, Wang SJ*. The prevalence and clinical phenotypes of cluster headache in relation with latitude. Current Pain and Headache Reports 2024 Mar 5. doi: 10.1007/s11916-024-01229-3
13. Aoh Y, Hou TW, Yang CC, Chang CM, Chen SP, Tsai IJ, Cheng CW, Yang CP*. Update on gepants for the treatment of chronic migraine. J Chin Med Assoc. 2024 Apr 1;87(4):350-356. doi: 10.1097/JCMA.0000000000001070.
14. Pan LL, Ling YH, Lai KL, Wang YF, Hsaio FJ, Chen SP, Liu HY, Chen WT, Wang SJ. The normative values of pain thresholds in healthy Taiwanese. Brain and Behavior Apr;14(4):e3485. doi: 10.1002/brb3.3485.
15. Tsai ET, Tseng HC, Liu YH, Wu YR, Peng SY, Lai WY, Lin YY, Chen SP, Chiou SH, Yang YP, Chien Y. Comparison of the mesodermal differentiation potential between embryonic stem cells and scalable induced pluripotent stem cells. J Chin Med Assoc. 2024 May 1;87(5):488-497. doi: 10.1097/JCMA.0000000000001082
16. Yang JC, Chen SP*, Wang YF, Chang CH, Fuh JL, Chow LH, Han CL*, Chen YJ*, Wang SJ.* Cerebrospinal fluid proteome map reveals molecular signatures of reversible cerebral vasoconstriction syndrome. Molecular & Cellular Proteomics 2024 Jun 3:100794. doi: 10.1016/j.mcpro.2024.100794. (*Equal contribution)
17. Wijeratne T, Tanprawate S, Singh L, Chen SP, Marteletti P. Unveiling a Groundbreaking Alliance: The Inaugural Collaboration between the Asian Regional Consortium of Headache and the Journal of Headache and Pain. The Journal of Headache and Pain 2024 Jul 30;25(1):125. doi: 10.1186/s10194-024-01816-0.
18. Wu CH, Chen SP, Chung CP, Yu KW, Lin TM, Luo CB, Lirng JF, Lee IH, Chang FC*. Early improvement in interstitial fluid flow in patients with severe carotid stenosis after angioplasty and stenting. Journal of Stroke 2024 Aug 30. doi: 10.5853/jos.2023.04203
19. Chen SP, Hsu CL, Chen TH, Pan LLH, Wang YF, Ling YH, Chen YM, Fann CSJ*, Wang SJ*. A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort. Communications Biology 2024 Aug 22;7(1):1034. doi: 10.1038/s42003-024-06603-w..
20. Wang YF, Yang FC, Chen LA, Chang TY, Su HC, Yang CP, Tu YH, Tzeng YS, Chen SP, Fuh JL, Lai KL, Ling YH, Chen WT, Wang SJ. Comparative effectiveness and tolerability of CGRP monoclonal antibodies and onabotulinumtoxinA in chronic migraine: a multicenter real-world study in Taiwan. European Journal of Neurology. 2024 Sep;31(9):e16372. doi: 10.1111/ene.16372.
21. Hsu HT, Cheng HC, Hou TW, Tzeng YS, Fuh JL, Chen SP, Chen WT, Lee WJ, Pai YW, Lee YC, Lirng JF, Wang SJ, Wang YF. Idiopathic Intracranial Hypertension in Asians: A Retrospective Dual-Center Study. The Journal of Headache and Pain 2024 Sep 4;25(1):144. doi: 10.1186/s10194-024-01852-w.
22. Lin PT, Hseu SS, Fuh JL, Lirng JF, Chen SP, Chen WT, Wang SJ*, Wang YF*. Sex differences in the clinical manifestations and treatment outcomes in a large cohort of spontaneous intracranial hypotension. Headache 2024 Sep 2. doi: 10.1111/head.14816.
23. Pan LLP, Chen SP, Ling YH, Wang YF, Lai KL, Liu HY, Chen WT, Huang WJ, Coppola G, Treede RD, Wang SJ. Salivary testosterone levels and pain perception exhibit sex-specific association in healthy adults but not in patients with migraine. The Journal of Pain 2024 Sep;25(9):104575. doi: 10.1016/j.jpain.2024.104575.

• Chiang CC, Chen SP. Migrainous infarction. Handbook in Clinical Neurology. 2024; 199, 465-474. doi: 10.1016/B978-0-12-823357-3.00021-5.

25. Ling YH, Chi NF*, Pan LLH, Wang YF, Wu CH, Lirng JF, Fuh JL, Wang SJ*, Chen SP*. Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome. The Journal of Headache and Pain. 2023 Dec 24:170. https://doi.org/10.1186/s10194-023-01694-y
26. Hsu SL, Liao YC, Wu CH, Chang FC, Chen YL, Lai KL, Chung CP, Chen SP*, Lee YC*. Impaired cerebral interstitial fluid dynamics in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Communications 2023 Dec 19;6(1):fcad349. doi: 10.1093/braincomms/fcad349.
27. Kuan AS, Chen SP, Wang YF, Wang SJ. Prolonged headache with vaccine- and dose-specific headache pattern associated with vaccine against SARS-CoV-2 in patients with migraine. Cephalalgia 2023 Oct;43(10):3331024231208110
28. Hsiao FJ, Chen WT, Wu YT, Pan LLH, Wang YF, Chen SP, Lai KL, Gianluca C, Wang SJ. Characteristic oscillatory brain networks for predicting patients with chronic migraine. The Journal of Headache and Pain. 2023 Oct 18;24(1):139. doi: 10.1186/s10194-023-01677-z.
29. Tsai ET, Peng SY, Chen CY, Liu YH, Tseng YH, Hsiao YJ, Tseng HC, Lai WY, Lin YY, Yang YP, Chien Y*, Chen SP, Chiou SH*. HLA-homozygous iPSC-derived mesenchymal stem cells rescue experimental Leber’s hereditary optic neuropathy model in vitro and vivo. Cells 2023 Nov 13;12(22):2617. doi: 10.3390/cells12222617.
30. Wang YF, Tzeng YS, Yu CC, Ling YH, Chen SP, Lai KL, Chen WT, Wang SJ. Sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache. The Journal of Headache and Pain. 2023 Nov 1;24(1):145. doi: 10.1186/s10194-023-01685-z.
31. Chen PY, Yen JC, Liu TT, Chen ST, Wang SJ, Chen SP*. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain 2023 July; 146(7): 2989–3002, doi: 10.1093/brain/awad045.
32. Wu CH, Hsu TW, Lai KL, Wang YF, Fuh JL, Wu HM, Lirng JF*, Wang SJ, Chen SP.* Disrupted brain functional status in patients with reversible cerebral vasoconstriction syndrome. Annals of Neurology 2023 Oct;94(4):772-784. doi: 10.1002/ana.26724.
33. Wu CH, Kuo Y, Chang FC, Lirng JF, Ling YF, Wang YF, Wu HM, Fuh JL, Lin CJ, Wang SJ*, Chen SP*. Noninvasive investigations of human glymphatic dynamics in a diseased model. European Radiology 2023 Jul 4. doi: 10.1007/s00330-023-09894-5.
34. Chen SP. Migraine and treatment-resistant depression. Progress in Brain Research. 2023;281:149-173. doi: 10.1016/bs.pbr.2023.05.001.
35. Winsvold BS, …Chen SP, … for the International Consortium for Cluster Headache Genetics. Cluster headache genome‐wide association study and meta‐analysis identifies eight loci and implicates smoking as causal risk factor. Annals of Neurology 2023 DOI: 10.1002/ana.26743
36. Kuan AS, Chen SP, Wang YF, Wang SJ. Prolonged headache with vaccine- and dose-specific headache pattern associated with vaccine against SARS-CoV-2 in patients with migraine. Cephalalgia 2023 Oct;43(10):3331024231208110
37. Hsu SL, Liao YC, Wu CH, Chang FC, Chen YL, Lai KL, Chung CP, Chen SP*, Lee YC*. Glymphatic dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Communications 2023 in press
38. Hsiao FJ, Chen WT, Wu YT, Pan LLH, Wang YF, Chen SP, Lai KL, Gianluca C, Wang SJ. Characteristic oscillatory brain networks for predicting patients with chronic migraine. The Journal of Headache and Pain. 2023 Oct 18;24(1):139. doi: 10.1186/s10194-023-01677-z.
39. Wang YF, Tzeng YS, Yu CC, Ling YH, Chen SP, Lai KL, Chen WT, Wang SJ. Sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache. The Journal of Headache and Pain. 2023 Nov 1;24(1):145. doi: 10.1186/s10194-023-01685-z.
40. Chen SP,^¶ Takizawa T,^¶ Sekiguchi K, Nakahara Jin, Wang SJ*. COVID-19 vaccination elicited de novo and recurrence of cluster headache: a case series. Cephalalgia 2023 in press
41. Hsiao FJ, Chen WT, Wang YF, Chen SP, Lai KL, Gianluca C, Wang SJ*. Identification of patients with chronic migraine by using sensory-evoked oscillations from the electroencephalogram classifier. Cephalalgia 2023 May. 43(5): 1–11
42. Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LLH, Wang SJ, Lai KL*. Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study. Cephalalgia 2023 Oct;43(10):3331024231206781.
43. Lange K, Choi SY, Ling YH, Chen SP, Mawet J, Duflos C, Lee MJ, Ducros A, Wang SJ*, Pezzini A*. Reversible cerebral Vasoconstriction syndrome intERnational CollaborativE (REVERCE) network: study protocol and rationale of a multicentre research collaboration. European Stroke Journal
44. Chen YJ, Hu KF, Chan C, Huang C, Huan YH, Wang YF, Wang SJ, Chen SP*, Lee MH*. Association of Periodontal Disease with Migraine: A Large-Scale Community-Based Cross-Sectional Study. Headache 2023 Apr;63(4):539-548. doi: 10.1111/head.14491. (*equal contribution)
45. Wu JW, Chen ST, Wang YF, Lai KL, Chen TY, Chen SP, Chen WT, Wang SJ*. Sphenopalatine Ganglion Volumetry in Episodic Cluster Headache: From Symptom Laterality to Cranial Autonomic Symptoms. The Journal of Headache and Pain. 2023; 24:2
46. Lin PT, Wang YF*, Hseu SS, Fuh JL, Lirng JF, Wu JW, Chen ST, Chen SP, Chen WT, Wang SJ. The SIH-EBP Score: A Grading Scale to Predict the Response to the First Epidural Blood Patch in Spontaneous Intracranial Hypotension. Cephalalgia 2023 Mar;43(3):3331024221147488.
47. Lin PT, Chen SP, Wang SJ*. Update on sex-induced headache and primary thunderclap headache. Cephalalgia 2023, 43(3): 1–10
48. Wang YF *, Tzeng YS, Yu CC, Ling YH, Chen SP, Lai KL, Wang SJ. Clinical utility of Leeds Dependence Questionnaire in medication-overuse headache. Diagnostics 2023, 13(3), 472; https://doi.org/10.3390/diagnostics13030472
49. Tsao YC, Wang YF, Fuh JL, Chen WT, Lai KL, Liu HY, Wang SJ*, Chen SP*. Transient visual disturbance is associated with disability and suicidal risk in patients with migraine without aura. Journal of the Chinese Medical Association 2023 Jun 1;86(6):557-564. doi: 10.1097/JCMA.0000000000000912.
50. Chou TM, Lee ZF, Wang SJ, Lien CC*, Chen SP*. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. The Journal of Headache and Pain. 2022; 23:157 https://doi.org/10.1186/s10194-022-01531-8
51. Chen SP*, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. Journal of Biomedical Science. 2022; 29:72
52. Tsao YC, Wang YF, Fuh JL, Chen WT, Lai KL, Liu HY, Wang SJ, Chen SP*. Non-aura visual disturbance with high visual aura rating scale scores has stronger association with migraine chronification than typical aura. Cephalalgia 2022 Nov 23, 42(14) 1487–1497
53. Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LLH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CSJ, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan. The Journal of Headache and Pain 2022; 23:147. https://doi.org/10.1186/s10194-022-01517-6
54. Jiang YJ^¶, Fann CSJ^¶; Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP*, Wang SJ*. Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. The Journal of Headache and Pain. 2022 Mar 29;23(1):39 doi: 10.1186/s10194-022-01409-9. (*equal contribution; ^¶ equal contribution).
55. Tsao YC, Wang SJ, Hsu CL, Wang YF, Fuh JL, Chen SP*, Fann CSJ*. Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population. Cephalalgia 2022 Mar;42(3):229-238. doi: 10.1177/03331024211037269 (*equal contribution)
56. Hsiao FJ*, Chen WT*, Pan LLH, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G, Wang SJ. Resting‑state magnetoencephalographic oscillatory connectivity to identify patients with chronic migraine using machine learning. The Journal of Headache and Pain 2022; 23:130. https://doi.org/10.1186/s10194-022-01500-1.
57. Liu HY, Lee PL, Chou KH, Wang YF, Chen SP, Lai KL, Pan LL, Lin CP, Wang SJ, Chen WT*. Brain morphometry changes with fatigue severity in fibromyalgia. Clin Exp Rheumatol. 2022 Sep 6. doi: 10.55563/clinexprheumatol/zviutu
58. Liu TT, Morais A, Takizawa T, Mulder I, Simon B, Chen SP, Wang SJ, Ayata C*, Yen JC*. Efficacy of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model. The Journal of Headache and Pain. 2022 Jan 21;23(1):12. doi: 10.1186/s10194-022-01384-1.
59. Wang YF, Liao YC, Tzeng YS, Chen SP, Lirng JF, Fuh JL, Chen WT, Lai KL, Lee YC*, Wang SJ*. Mutation screening and association analysis of NOTCH3R544C in patients with migraine with or without aura. Cephalalgia 2022 Aug;42(9):888-898. doi: 10.1177/03331024221080891.
60. Pan LLH, Wang YF, Ling YH, Lai KL, Chen SP, Chen WT, Treede RD, Wang SJ*. Pain sensitivities predict prophylactic treatment outcomes of flunarizine in chronic migraine patients: a prospective study. Cephalalgia. 2022 Aug;42(9):899-909. doi: 10.1177/03331024221080572.
61. Pan LLH, Chen WT, Wang YF, Chen SP, Lai KL, Liu HY, Hsiao FJ*, Wang SJ*. Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine. 2022 Jul 1;163(7):1324-1334. doi: 10.1097/j.pain.0000000000002516.
62. Tu YH, Wang YF, Yuan HK, Chen SP, Tzeng YS, Chen WT, Lai KL, Ling YH, Wang SJ. Most bothersome symptoms in patients with migraine: a hospital-based study in Taiwan. Headache 2022 May;62(5):596-603. doi: 10.1111/head.14308.
63. Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF. Fibroblasts drive metabolic reprogramming in pacemaker cardiomyocytes. Circulation Research 2022 Jun 24;131(1):6-20. doi: 10.1161/CIRCRESAHA.121.320301.
64. Liu HY, Chou KH, Lee PL, Wang YF, Chen SP, Lai KL, Lin CP, Wang SJ, Chen WT. Right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain 2022 Apr 1;163(4):e572-e579. doi: 10.1097/j.pain.0000000000002409.
65. Hsiao FJ, Chen WT, Pan H. LL, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G., Wang SJ. Dynamic brainstem and somatosensory cortical excitability during migraine cycles. The Journal of Headache and Pain. 2022 Jan. 23(1), 1-12
66. Liaw YC, Wang YF, Chen WT, Chen SP, Wu JW, Chen ST, Lai KL, Fuh JL, Wang SJ*. Sex-related differences in cluster headache: a hospital-based study in Taiwan. Cephalalgia 2022 Dec;42(14):1532-1542. doi: 10.1177/03331024221120054
67. Lin YL, Wong WY, Yang ZS, Wang SJ, Chen SP, Cheng JK, Lu H, Lien CC*. Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain. eLife 2022 Nov 15;11:e78610. doi: 10.7554/eLife.78610.
68. Wu CH, Wu HM, Ling YH, Wang YF, Fuh JL, Lin CJ, Ling K, Lirng JF, Wang SJ, Chen SP*. Blood brain barrier permeability in patients with reversible cerebral vasoconstriction syndrome assessed with dynamic contrast-enhanced MRI. Neurology 2021 Nov 2;97(18):e1847-e1859.
69. Wu CH, Lirng JF, Ling YH, Wang YF, Wu HM, Fuh JL, Lin PC, Wang SJ*, Chen SP*. Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood-brain barrier leakage. Annals of Neurology 2021;89:111–124 (*Equal contribution)
70. Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD*, Wang SJ*. Circulating microRNAs associated with Reversible Cerebral Vasoconstriction Syndrome. Annals of Neurology 2021;89:459–473
71. Hsiao FJ, Chen WT, Wang YF, Chen SP, Lai KL, Liu HY, Pan LH, Wang SJ. Somatosensory gating responses are associated with prognosis in patients with migraine. Brain Sciences 2021 Jan 28;11(2):166. doi: 10.3390/brainsci11020166.
72. Lee ZF, Huang TH, Chen SP*, Cheng IH*. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling. Pain 2021 Jun 1;162(6):1669-1680. (*Equal contribution)
73. Hsiao FJ, Chen WT, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G, Wang SJ. Migraine chronification is associated with beta-band connectivity within the pain network. Pain 2021 Oct 1;162(10):2590-2598.
74. Ling YH, Wang YF, Lirng JF, Fuh JL, Wang SJ, Chen SP*. Post-reversible cerebral vasoconstriction syndrome headache. The Journal of Headache and Pain. 2021; 22(1): 1-8
75. Lin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP*, Wang SJ*. Diagnosis and Classification of Headache Associated with Sexual Activity Using a Composite Algorithm: a cohort study. Cephalalgia 2021 Dec;41(14):1447-1457 (*Equal contribution)
76. Wang YF, Yu CC, Kuan AS, Chen SP, Wang SJ. Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study. The Journal of Headache and Pain 2021 May 10;22(1):36. doi: 10.1186/s10194-021-01248-0.
77. Yen HH, Chien C, Lee IH, Chen SP, Luo CB, Lin CJ, Chen ST, Yuan WH, Kuo Y, Wu CH*, Chang FC*. Application of flat-panel volume computed tomography to evaluate cerebral hemorrhage after mechanical thrombectomy of acute embolic stroke of the anterior circulation. J Comput Assist Tomogr 2021 Nov-Dec 01;45(6):919-925.
78. Liu YH, Guo YC, Lin LY, Tsai CP, Fuh JL, Wang YF, Chen SP, Wu HM, Yu KW, Lin KP, Wang SJ, Liao YC*, Lee YC*. Treatment response, risk of relapse, and clinical characteristics of Taiwanese patients with neuromyelitis optica spectrum disorder. Journal of the Formosan Medical Association 2021 Nov 18;S0929-6646(21)00499-X. doi: 10.1016/j.jfma.2021.11.002.
79. Tai CS, Wu SL, Lin SY, Liang Y, Wang SJ, Chen SP*. The causal-effect of bed rest and post-dural puncture headache in patients receiving diagnostic lumbar puncture- A prospective cohort study. Journal of the Chinese Medical Association 2021 Aug 1;84(8):791-794.
80. Liu HY, Chou KH, Lee PL, Wang YF, Chen SP, Lai KL, Lin CP, Wang SJ, Chen WT. The right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain 2021 Jul 13. doi: 10.1097/j.pain.0000000000002409.
81. Ling YH, Chen SP*. Narrative Review: Headaches after Reversible Cerebral Vasoconstriction Syndrome. Current Pain and Headache Reports. 2020;24 (12), 1-4
82. Hsiao FJ, Chen WT, Ko YC, Liu HY, Wang YF, Chen SP, Lai KL, Lin HY, Coppola G, Wang SJ. Neuromagnetic amygdala response to pain-related fear as a brain signature of fibromyalgia. Pain Ther. 2020 Oct 22. doi: 10.1007/s40122-020-00206-z
83. Hsiao FJ, Chen WT, Liu HY, Wang YF, Chen SP, Lai KL, Pan LL, Wang SJ. Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study. The Journal of Headache and Pain 2020; 21:133. https://doi.org/10.1186/s10194-020-01200-8
84. Cho SH^¶, Ling YH^¶, Lee MJ^¶, Chen SP^¶, Fuh L, Lirng JF, Cha JH, Wang YF, Wang SJ*, Chung CS*. Temporal profile of blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome. Stroke 2020 May;51(5):1451-1457. (^¶Equal contribution)
85. Hsu WH, Wang SJ, Chao YM, Chen CJ, Wang YF, Fuh JL, Chen SP*, Lin YL. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia 2020 Jun; 40(7):735-747.
86. Huang C^¶, Chen SP^¶, Huang YH, Chen HY, Wang YF, Lee MH*, Wang SJ.* HLA class I alleles are associated with chronic migraine and medication overuse in migraineurs. Cephalalgia 2020 April. 40(5) 493–502. (^¶Equal contribution)
87. Liu JH, Wang TW, Lin YY, Ho WC, Tsai HC, Chen SP, Lin AM, Liu TY, Wang HT. Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation. Experimental Neurology 2020 Jan;323:113066.
88. Sprouse Blum AS, Lavoie B, Haag M, Mawe SM, Tolner EA, van den Maagdenberg AM., Chen SP, Eikermann-Haerter K, Ptáček L., Mawe GM, Shapiro RA. No gastrointestinal dysmotility in transgenic mouse models of migraine. Headache 2020 Feb;60 (2): 396-404
89. Morais A, Liu TT, Qin T, Sadhegian H, Ay I, Yagmur D, Mendes da Silva R, Chung D, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC*, Ayata C*. Vagus nerve stimulation inhibits cortical spreading depression exclusively via central mechanisms. Pain 2020 Jul;161 (7):1661-1669
90. Liu HY, Lee PL, Chou KH, Lai KL, Wang YF, Chen SP, Chen WT*, Wang SJ*. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine. The Journal of Headache and Pain. 2020 Mar 18;21(1):29.
91. Peng KP*, Chen SP, Gudmundsson LS. Headache highlights 2019: Junior editors’ choice. Cephalalgia Reports 2020: 3, 2515816320903292
92. Wu JW, Wang YF, Hseu SS, Chen ST, Chen YL, Wu YT, Chen SP, Lirng JF, Wang SJ*. Brain volume changes in spontaneous intracranial hypotension: revisiting the Monro-Kellie Doctrine. Cephalalgia 2020 in press
93. Pan YJ, Chen YC, Lu SR, Juang KD, Chen SP, Wang YF, Fuh JL, Wang SJ*. The influence of friendship on migraine in young adolescents: a social network analysis. Cephalalgia 2020 Jul 7:333102420940700. doi: 10.1177/0333102420940700.
94. Pan LL, Wang YF, Lai KL, Chen WT, Chen SP, Ling YH, Chou LW, Treede RD, Wang SJ*. Mechanical punctate pain threshold is associated with headache frequency and phase in patients with migraine. Cephalalgia 2020 Aug;40(9):990-997

Huang WC, Chen SP, Wang SJ*. Are surgically remediable headaches associated with cervical spondylosis equivalent to “cervicogenic headaches”? Neurospine 2020 Jun;17(2):374-376