Professor

Szu-Ting Chen

Szu-Ting Chen Associate Professor

Immunology, Infection, Molecular Medicine
chensztin@nycu.edu.tw
(02)28267045

lab
  • Ph.D., Graduate Institute of Microbiology and Immunology, College of Life Science, National Yang-Ming University, 2009/1
  • Postdoctoral Fellow, Genomics Research Center, Academia Sinica, 2009-2012
  • Postdoctoral Fellow, Lineberger Comprehensive Cancer center University of North Carolina at Chapel Hill, USA, 2012/7-2014//7
  • Assistant Professor, College of Medicine, Department of Microbiology and Immunology, Taipei Medical University 2014/8-2015/7
  • Visiting position with a title of Assistant Professor Scholar, Genomic Research Center, Academia Sinica, 2014/9~2016/8
  • Assistant Professor, Institute of Clinical Medicine, National Yang-Ming University, 2015/8~ 2020/1
  • Associate Professor, Institute of Clinical Medicine, National Yang-Ming University, 2020/2~
  • 2023, Wu Ho-Su TBF Taiwan Bio-development Foundation Medical Award
  • 2023, Travel Grant Winner, 15TH International Congress on Systemic Lupus Erythematosus
  • 2020, College Student Research Creativity Award, Ministry of Science and Technology
    (指導學生獲得109學年度科技部大專生研究計畫研究創作獎, 2020)
  • 2019, Outstanding Research Scholar Award, Chinese Society of Immunology
  • 2017, Project for Excellent Junior Research Investigators, Ministry of Science and Technology
    (科技部優秀年輕學者研究計畫, 2017-2020)
  • 2012, Award of Postdoctoral Research Abroad Program-2 years, “National Science Council”, TW
    (國科會補助赴國外從事博士後研究，千里馬計畫兩年期)
  • 2009, Award of Long –Term Smile Contest, “Acer Foundation”, TW
  • 2009, Outstanding Thesis award, “Chien-Tien Hsu Foundation” in the Chinese society of cell and molecular biology, TW
  • 2009, Distinguished Thesis award, “Tiente Lee Biomedical Foundation”, TW
  • 2009, Outstanding Thesis award, Yang-Ming University, TW
  • 2006, Zong-Ren Chen Immunology of Research & Development Foundation, TW

The research focuses in our team are mainly in the neutrophil and dendritic cell biology in human diseases. We have been investigating the impact of the dysregulated immune responses in terms of the overzealous neutrophil activation and type I IFN signaling cascade in the autoimmune disease and infectious diseases. The innate immune checkpoint, NLRP12 currently gains immense attention due its novel biological functions in regulating the immune resilience and maintaining the immune homeostasis. We have claimed that NLRP12 is involved in the pathogenesis of lupus nephritis in an IFN-I dependent manner. This protein is a member of NLR superfamily but is with the opposite role in the inflammasome activation as NLRP3. We are investigating the molecular mechanisms of NLRP12 in modulating the neutrophil activation in an IFN signaling dependent manner and its impact in the infectious diseases and autoimmune diseases. In addition, we also focus on a Syk coupled C-type lectin receptors (Syk-CLRs), CLEC5A which is a protective host factor in the anti-bacterial infection. Its novel roles in the activation of cytotoxic T cell and differentiation of γδ T 17 cell driven by the cross antigen presentation in dendritic cell bring about the potential application in the manipulating the host immunity in the aspect of anti-tumor immunity and immune senescence.

We have been publishing the interesting articles in the Cell Host and Microbes, Nature Communication, and Journal of Clinical Investigation. You are welcome to contact with us and joint our research team.

Chen, Szu-Ting | TEDxTaoyuan