實驗室簡介
Research interests：https://cstlab.weebly.com/
EDUCATION AND POSITIONS HELD:
- Ph.D., Graduate Institute of Microbiology and Immunology, College of Life Science, National Yang-Ming University, 2009/1
- Postdoctoral Fellow, Genomics Research Center, Academia Sinica, 2009-2012
- Postdoctoral Fellow, Lineberger Comprehensive Cancer center University of North Carolina at Chapel Hill, USA, 2012/7-2014//7
- Assistant Professor, College of Medicine, Department of Microbiology and Immunology, Taipei Medical University 2014/8-2015/7
- Visiting position with a title of Assistant Professor Scholar, Genomic Research Center, Academia Sinica, 2014/9~2016/8
- Assistant Professor, Institute of Clinical Medicine, National Yang-Ming University, 2015/8~ 2020/1
- Associate Professor, Institute of Clinical Medicine, National Yang-Ming University, 2020/2~
HONORS:
- Distinguished Thesis award, “Tiente Lee Biomedical Foundation”, 2009
- Outstanding Thesis award, Distinction. “Chien-Tien Hsu Foundation” in the Chinese society of cell and molecular biology, 2009
- Travel fund for RCAI International Summer Program “RIKEN YOKOHAMA Institute”, 2009
- Award of Long –Term Smile Contest, “Acer Foundation”, 2009
- Award of Postdoctoral Research Abroad Program-2 years, “National Science Council”, 2012-2014.
- Outstanding Yong Investigator Grant, Ministry of Science and Technology, Taiwan, 2017~
- Medical Student-Elected Excellent Teaching Award, NYMU School of Medicine, 2020, 2022
- Outstanding research scholar of Chinese Society of Immunology in 2019.
RESEARCH INTERESTS:
The research focuses in our team are mainly in the neutrophil and dendritic cell biology in human diseases. We have been investigating the impact of the dysregulated immune responses in terms of the overzealous neutrophil activation and type I IFN signaling cascade in the autoimmune disease and infectious diseases. The innate immune checkpoint, NLRP12 currently gains immense attention due its novel biological functions in regulating the immune resilience and maintaining the immune homeostasis. We have claimed that NLRP12 is involved in the pathogenesis of lupus nephritis in an IFN-I dependent manner. This protein is a member of NLR superfamily but is with the opposite role in the inflammasome activation as NLRP3. We are investigating the molecular mechanisms of NLRP12 in modulating the neutrophil activation in an IFN signaling dependent manner and its impact in the infectious diseases and autoimmune diseases. In addition, we also focus on a Syk coupled C-type lectin receptors (Syk-CLRs), CLEC5A which is a protective host factor in the anti-bacterial infection. Its novel roles in the activation of cytotoxic T cell and differentiation of γδ T 17 cell driven by the cross antigen presentation in dendritic cell bring about the potential application in the manipulating the host immunity in the aspect of anti-tumor immunity and immune senescence.
We have been publishing the interesting articles in the Cell Host and Microbes, Nature Communication, and Journal of Clinical Investigation. You are welcome to contact with us and joint our research team.
“發炎”目前已公認為一切疾病的元兇，時代雜誌更是以此為封面標題，闡明發炎與各種疾病的連結。我們的研究工作探討發炎疾病的起始包含:宿主與病原菌(病毒及細菌)或是自身環境因子引起之刺激物之間的交互作用。透過免疫細胞分析平台及免疫細胞受體分析，探討免疫細胞在發炎疾病扮演的角色。尋找因過度發炎反應造成組織器官受損的可能治療標的。
歡迎觀看
終結細胞激素風暴：讓我們告別自體免疫疾病 | 陳斯婷 Chen, Szu-Ting | TEDxTaoyuan
恭賀 陳斯婷老師研究團隊 重要研究成果發表於 <<細胞宿主與微生物>> 期刊